Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes

Investigating the Effect of Various Oxidizing Agents on the Surface Functionalization of Microporous Polypropylene Membranes

Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that causes altered heart morphology, circulatory impairment, edema, hemorrhage, and early life stage mortality in fish. TCDD toxicity is dependent, in large part, on the aryl hydrocarbon receptor (AHR), but understanding of the molecular mechanism of cardiovascular embryotoxicity remains incomplete. To identif...

Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration

Zebrafish display a distinct ability to regenerate their heart following injury. However, this ability is not shared by another teleost, the medaka. In order to identify cellular and molecular bases for this difference, we performed comparative transcriptomic analyses following cardiac cryoinjury. This comparison points to major differences in immune cell dynamics between these models. Upon clo...

Biological interpretations of transcriptomic profiles in mammalian oocytes and embryos.

The characterization of gene-expression profiles in oocytes and embryos is critical to understand the influence of genetic and environmental factors on preimplantation and fetal development. Numerous gene-expression microarray studies using different platforms and species are offering insights into the biological processes extensively represented among the genes exhibiting differential expressi...

osteoclast-like cells in early zebrafish embryos

objective: genes involved in bone and tissue remodelling in the vertebrates include matrix metalloproteinase-9 (mmp-9), receptor activator of necrosis factor κ-β (rank), cathepsin-k (ctsk) and tartrate-resistant acid phosphatase (tracp). we examine whether these markers are expressed in cells of zebrafish embryos of 1-5 days post fertilization. we also examine adult scales, which are known to c...